Atherosclerosis is lipoprotein metabolism disorder which is marked by an
increase of total cholesterol level in blood serum. Cowpea contains a lot of
isoflavones that can inhibit the activity of the enzyme HMG-CoA reductase in
the cholesterologenesis process. The aim of this study is to find out cowpea
yogurt which can prevent the increasing total cholesterol level. This study
used an experimental study with a post-test only control group design in 30
male rats. It was divided into 5 groups: Results showed that the total
cholesterol level among the fifth group was a significant difference (KruskalWallis, p = 0,000). The conclusion of this study is cowpea yogurt can prevent
the increasing total cholesterol levels of Wistar rats induced by a high-fat
diet.

Keywords:
Cowpea yogurt; Vigna
unguiculate; Total
cholesterol; Atherosclerosis